Home » NFL » Matchups » Buffalo Bills vs San Francisco 49ers Buffalo Bills 49ersView current matchupPrevious Matchups December 7, 20207/12/20203.15 PM ESTState Farm Stadium October 16, 201616/10/20168.00 AM ESTHighmark Stadium October 7, 20127/10/201211.25 AM ESTCandlestick Park November 30, 200830/11/20088.00 AM ESTHighmark StadiumView current matchupBuffalo Bills vs 49ers Betting Odds WIN PROBABILITY PREDICTED SCORE BETTING TRENDS SPORTS TRENDS RETURN ON INVESTMENTLAST 10 GAMES Buffalo Bills 49ers RECORDS​ HEAD TO HEAD TEAM RANKED STATSREGULAR SEASON Buffalo Bills 49ers TEAM LEADERS Buffalo Bills 49ers INJURIES Buffalo Bills 49ers Buffalo BillsVISIT TEAM PAGE49ersVISIT TEAM PAGELATEST NFL NEWS OMAHA, SET! The 2024 Las Vegas Raiders Schedule NFL 2024 Preview Week 3: Ravens vs Cowboys Takes Center Stage 2024 NFL Cheat Sheet: San Francisco 49ers Stats & Odds NFL 2024 Preview Week 2: Bills vs Dolphins on Tap Thursday Night 2024 NFL Cheat Sheet: Tampa Bay Buccaneers Stats & Odds NFL 2024 Week 1 Preview: Lines and Totals Released 2024 NFL Cheat Sheet: New York Jets Stats & Odds Davante Adams Receiving Props, Can He Reach 1000 Yards? Will A Change of Scenery Benefit Speedy WR Jerry Jeudy? Can Ja’Marr Chase Be the NFL’s Top Receiver in 2024?